vacuolar protein sorting 25 homologGenealiases: DERP9 · EAP20 · FAP20
Q-omics provides the consensus-scored VPS25 profile across patient tissues and cancer cell-line models. VPS25 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, VPS25 is differentially expressed in 13, with the highest sampling consensus in BLCA. Additionally, VPS25 RNA expression shows 18,592 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight HNSC, BLCA, and ACC as cancer lineages where VPS25 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for VPS25 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes VPS25 survival associations across molecular data types. VPS25 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible VPS25 RNA expression–survival associations across cancer types. High VPS25 expression shows unfavorable associations in HNSC, LIHC, BLCA, KIRC and ACC, but favorable associations in COAD. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for VPS25 RNA expression.
This table summarizes VPS25 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRP for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for VPS25. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. VPS25 shows lower tumor expression in KICH and higher tumor expression in BLCA, KIRP, LIHC, LUAD and LUSC. The BLCA box plot shows higher VPS25 RNA expression in tumor versus normal tissue (log2 FC = +1.018, t-test p < 0.001).
This table shows molecular features associated with VPS25 in patient tissues and cancer cell lines. In patient samples, VPS25 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, VPS25 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in SKIN and UPPER_AERODIGESTIVE_TRACT.
