VPS25

Across TCGA pan-cancer cohorts, VPS25 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated VPS25 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher VPS25 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated VPS25 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where VPS25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	35	view →
PDAC	DFS	Tertile	II,III,IV	0.865	0.624	.002	33	view →
LUAD	DFS	Median	All	0.955	0.641	.006	12	view →
HNSC	OS	Quartile	All	0.526	0.776	.013	9	view →
OV	DFS	Tertile	All	0.807	1.000	.038	8	view →
UCEC	OS	Tertile	All	1.000	0.911	.044	2	view →
LSCC	DFS	Median	All	0.849	0.728	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

VPS25–CCRCC (DFS)

Open the CCRCC breakdown →