VPS25

Across TCGA pan-cancer cohorts, VPS25 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated VPS25 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher VPS25 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated VPS25 expression acts as an unfavorable survival marker.

PAAD and CESC are the cancer types where VPS25 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Median	All	0.100	0.486	<.001	24	view →
CESC	OS	Median	III,IV	0.068	0.756	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

VPS25–PAAD (DFS)

Open the PAAD breakdown →