VPS25

Across TCGA patient cohorts, VPS25 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible VPS25-associated genes across cancer lineages are KIR3DL1, PMS2P6, and LINC01543. Each is linked with VPS25 in more than 1 cancer types. Because this analysis shows association rather than direction, both VPS25-to-partner and partner-to-VPS25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR3DL1 grouped by VPS25-low versus VPS25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS25→partner) and Y-score (partner→VPS25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIR3DL1 →	+0.294	+3.718	<.001	.003	3	1
UCEC	PMS2P6 →	+0.306	+3.304	<.001	.001	3	1
UCEC	LINC01543 →	+0.256	+3.026	<.001	.005	3	1
UCEC	MIR4690 →	+0.668	+2.735	<.001	.006	3	1
UCEC	EML2-AS1 →	+0.078	+2.592	.003	.009	3	1
UCEC	MIA-RAB4B →	+0.121	+2.863	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

KIR3DL1 by VPS25 expression — UCEC

Explore this box plot interactively →