VPS25

Across TCGA pan-cancer cohorts, VPS25 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of VPS25’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where VPS25 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types VPS25 is over-expressed in tumor, although a few such as LUAD and CCRCC show the opposite, repressed pattern.

LUAD, CCRCC, and LSCC are the cancer types where VPS25 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in VPS25 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.264	<.001	9	view →
CCRCC	All	All	−0.126	<.001	9	view →
LSCC	Female	All	−0.252	<.001	8	view →
HNSC	Male	II,III,IV	−0.178	<.001	8	view →
PDAC	Male	All	−0.309	<.001	7	view →
COAD	Male	II,III,IV	−0.213	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

VPS25–LUAD

Open the LUAD breakdown →