VPS25

Across TCGA patient cohorts, VPS25 protein abundance is significantly associated with the RNA expression of many other genes, with 5,857 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible VPS25-associated genes across cancer lineages are VPS36, COG3, and HSF2BP. Each is linked with VPS25 in more than 4 cancer types. Because this analysis shows association rather than direction, both VPS25-to-partner and partner-to-VPS25 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, VPS25 versus VPS36 in GBM, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (VPS25→partner) and Y-score (partner→VPS25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VPS36 →	+0.467	+0.236	<.001	<.001	3	5
BRCA	COG3 →	+0.633	+0.291	<.001	<.001	3	4
LUAD	HSF2BP →	-0.541	-0.155	.001	<.001	3	4
BRCA	SPRYD7 →	+0.422	+0.270	<.001	<.001	3	4
PDAC	ARPC5L →	-0.387	-0.189	<.001	.004	3	4
BRCA	SKA1 →	-1.131	-0.284	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,857 associations by consensus.

VPS25 vs VPS36 — GBM

Explore this scatter interactively →