spindlin interactor and repressor of chromatin bindingGenealiases: C11orf84 · SPIN-DOC
Q-omics provides the consensus-scored SPINDOC profile across patient tissues and cancer cell-line models. SPINDOC expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, SPINDOC is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, SPINDOC RNA expression shows 18,897 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRP, HNSC, and ACC as cancer lineages where SPINDOC shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPINDOC — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPINDOC survival associations across molecular data types. SPINDOC RNA expression shows survival associations in the most cancer types (28), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPINDOC RNA expression–survival associations across cancer types. High SPINDOC expression shows unfavorable associations in KIRP, MESO, ACC, KIRC, LIHC and BRCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for SPINDOC RNA expression.
This table summarizes SPINDOC tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 3. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for SPINDOC. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPINDOC shows higher tumor expression in HNSC, COAD, KIRP, KIRC, BLCA and LIHC. The HNSC box plot shows higher SPINDOC RNA expression in tumor versus normal tissue (log2 FC = +2.136, t-test p < 0.001).
This table shows molecular features associated with SPINDOC in patient tissues and cancer cell lines. In patient samples, SPINDOC shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, SPINDOC RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and BLOOD_Leukemia.
