SPINDOC

Across TCGA pan-cancer cohorts, SPINDOC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPINDOC data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SPINDOC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPINDOC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

GBM, HNSC, and OV are the cancer types where SPINDOC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.560	0.825	<.001	34	view →
HNSC	DFS	Median	III,IV	0.546	0.915	.013	16	view →
OV	DFS	Tertile	All	0.818	1.000	.038	8	view →
CCRCC	DFS	Median	All	1.000	0.615	.025	4	view →
LUAD	OS	Median	II,III,IV	1.000	0.857	.005	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPINDOC–GBM (DFS)

Open the GBM breakdown →