SPINDOC

Across TCGA patient cohorts, SPINDOC mutation is significantly associated with the RNA expression of many other genes, with 1,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINDOC-associated genes across cancer lineages are MIR3929, SEPTIN14P17, and RNA5SP192. Each is linked with SPINDOC in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3929 grouped by SPINDOC-low versus SPINDOC-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR3929 →	+1.276	+4.364	<.001	.006	3	3
BRCA	SEPTIN14P17 →	+0.191	+4.575	<.001	.009	3	2
BRCA	RNA5SP192 →	+0.286	+4.926	<.001	.005	3	2
BRCA	MIR617 →	+0.455	+4.721	<.001	.007	3	2
LUAD	LINC01941 →	+0.186	+4.742	<.001	.001	3	2
LUAD	RNU6-781P →	+0.528	+4.303	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,290 associations by consensus.

MIR3929 by SPINDOC expression — CESC

Explore this box plot interactively →