SPINDOC

Across TCGA cell cohorts, SPINDOC protein abundance is significantly associated with the go_rna of many other GO terms, with 2,842 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPINDOC-associated GO terms across cancer lineages are Response to Thyroglobulin triiodothyronine, Regulation of apoptotic signaling pathway, and Actomyosin structure organization. Each is linked with SPINDOC in more than 4 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to Thyroglobulin triiodothyronine grouped by SPINDOC-low versus SPINDOC-high in STOMACH.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Response to Thyroglobulin triiodothyronine →	+0.238	+0.710	<.001	.003	3	4
BLOOD_Lymphoma	Regulation of apoptotic signaling pathway →	+0.068	+0.920	<.001	<.001	3	4
STOMACH	Actomyosin structure organization →	+0.141	+0.800	.002	.001	3	4
LARGE_INTESTINE	Meiotic chromosome separation →	-0.111	-0.438	.006	.005	2	5
PANCREAS	Positive regulation of protein localization to mitochondrion →	+0.127	+0.508	<.001	.008	2	5
BLOOD_Leukemia	Protein localization to photoreceptor outer segment →	+0.177	+0.820	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,842 associations by consensus.

Response to Thyroglobulin triiodothyronine by SPINDOC expression — STOMACH

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