SPINDOC

Across TCGA patient cohorts, SPINDOC RNA expression is significantly associated with the protein abundance of many other proteins, with 17,257 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPINDOC-associated proteins across cancer lineages are RACGAP1, FEN1, and GINS3. Each is linked with SPINDOC in more than 7 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINDOC versus RACGAP1 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RACGAP1 →	+0.653	+0.747	<.001	<.001	3	8
OV	FEN1 →	+0.658	+0.441	<.001	<.001	3	8
OV	GINS3 →	+0.810	+0.580	<.001	<.001	3	8
OV	MCM2 →	+0.731	+0.445	<.001	<.001	3	8
OV	MCM3 →	+0.880	+0.501	<.001	<.001	3	8
OV	MCM4 →	+0.793	+0.527	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,257 associations by consensus.

SPINDOC vs RACGAP1 — BRCA

Explore this scatter interactively →