SPINDOC

Across TCGA pan-cancer cohorts, SPINDOC mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPINDOC’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPINDOC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SPINDOC is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where SPINDOC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPINDOC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−0.529	<.001	7	view →
HNSC	All	III,IV	+0.533	.007	5	view →
LSCC	Female	All	+0.368	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SPINDOC–LUAD

Open the LUAD breakdown →