SPINDOC

Across TCGA patient cohorts, SPINDOC protein abundance is significantly associated with the RNA expression of many other genes, with 7,606 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPINDOC-associated genes across cancer lineages are TTK, CDCA3, and CENPA. Each is linked with SPINDOC in more than 4 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINDOC versus TTK in LUAD, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TTK →	+0.989	+0.282	.001	.001	3	5
UCEC	CDCA3 →	+0.847	+0.377	<.001	<.001	3	4
LUAD	CENPA →	+0.885	+0.248	.003	.007	2	5
LUAD	CDCA5 →	+1.118	+0.366	<.001	<.001	3	4
BRCA	INCENP →	+0.631	+0.236	.001	.001	3	4
OV	KIF15 →	+1.081	+0.497	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,606 associations by consensus.

SPINDOC vs TTK — LUAD

Explore this scatter interactively →