SPINDOC

Across TCGA cell cohorts, SPINDOC mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPINDOC-associated genes across cancer lineages are C2orf73, PRM1, and MYMK. Each is linked with SPINDOC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf73 grouped by SPINDOC-low versus SPINDOC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C2orf73 →	+0.076	+4.450	<.001	.001	3	1
OVARY	PRM1 →	+0.071	+5.196	<.001	.005	3	1
OVARY	MYMK →	+0.026	+5.807	<.001	.001	3	1
OVARY	DEFB133 →	+0.046	+5.196	.009	.005	3	1
LARGE_INTESTINE	PLA2G3 →	+1.319	+3.215	<.001	.009	3	1
LARGE_INTESTINE	TNRC6B →	+1.092	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

C2orf73 by SPINDOC expression — BLOOD_Leukemia

Explore this box plot interactively →