SPINDOC

Across TCGA cell cohorts, SPINDOC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,026 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPINDOC-associated GO terms across cancer lineages are Regulation of attachment of mitotic spindle microtubules to kinetochore, Positive regulation of attachment of mitotic spindle microtubules to kinetochore, and Microtubule cytoskeleton organization involved in mitosis. Each is linked with SPINDOC in more than 18 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of attachment of mitotic spindle microtubules to kinetochore grouped by SPINDOC-low versus SPINDOC-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.131	+0.766	<.001	<.001	3	19
BREAST	Positive regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.144	+0.769	<.001	<.001	3	19
BONE	Microtubule cytoskeleton organization involved in mitosis →	+0.122	+1.210	.006	<.001	3	19
BREAST	Positive regulation of mitotic cytokinesis →	+0.208	+1.332	<.001	<.001	3	18
KIDNEY	Positive regulation of cytokinesis →	+0.106	+0.875	<.001	<.001	3	18
LIVER	DNA strand elongation involved in DNA replication →	+0.149	+1.179	.002	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,026 associations by consensus.

Regulation of attachment of mitotic spindle microtubules to kinetochore by SPINDOC expression — CNS

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