SPINDOC

Across TCGA cell cohorts, SPINDOC protein abundance is significantly associated with the RNA expression of many other genes, with 5,363 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPINDOC-associated genes across cancer lineages are LAMB3, SLC9A3R1, and IQANK1. Each is linked with SPINDOC in more than 6 cancer types. Because this analysis shows association rather than direction, both SPINDOC-to-partner and partner-to-SPINDOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINDOC versus LAMB3 in STOMACH, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINDOC→partner) and Y-score (partner→SPINDOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LAMB3 →	+5.038	+0.836	.001	<.001	3	7
BREAST	SLC9A3R1 →	+1.601	+0.527	.005	<.001	3	5
BLOOD_Leukemia	IQANK1 →	+0.528	+0.827	.002	.001	3	5
BLOOD_Lymphoma	LRP12 →	+2.286	+0.797	.001	.001	3	5
BLOOD_Lymphoma	DCK →	-2.100	-0.740	<.001	<.001	3	5
BLOOD_Lymphoma	AQP3 →	+3.080	+1.010	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,363 associations by consensus.

SPINDOC vs LAMB3 — STOMACH

Explore this scatter interactively →