SAM and SH3 domain containing 1Genealiases: CAPOK · DUH · DUH1 · SH3D6A · dJ323M4.1
Q-omics provides the consensus-scored SASH1 profile across patient tissues and cancer cell-line models. SASH1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SASH1 is differentially expressed in 14, with the highest sampling consensus in HNSC. Additionally, SASH1 RNA expression shows 20,101 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, HNSC, and THYM as cancer lineages where SASH1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SASH1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SASH1 survival associations across molecular data types. SASH1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (7) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SASH1 RNA expression–survival associations across cancer types. High SASH1 expression shows unfavorable associations in OV and UCEC, but favorable associations in KIRC, UCS, HNSC and LUAD. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SASH1 RNA expression.
This table summarizes SASH1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SASH1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SASH1 shows lower tumor expression in HNSC, THCA, LUAD, KICH, LUSC and COAD. The HNSC box plot shows higher SASH1 RNA expression in normal versus tumor tissue (log2 FC = −1.853, t-test p < 0.001).
This table shows molecular features associated with SASH1 in patient tissues and cancer cell lines. In patient samples, SASH1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SASH1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in OVARY and LARGE_INTESTINE.
