SASH1

Across TCGA pan-cancer cohorts, SASH1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SASH1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SASH1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SASH1 is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where SASH1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SASH1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−1.102	<.001	12	view →
LUAD	Female	II,III,IV	−0.884	<.001	9	view →
LSCC	All	III,IV	−0.776	<.001	9	view →
PDAC	Male	II,III,IV	−0.298	.002	4	view →
CCRCC	Male	All	+0.206	<.001	4	view →
OV	All	All	−0.659	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SASH1–HNSC

Open the HNSC breakdown →