SASH1

Across TCGA pan-cancer cohorts, SASH1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SASH1 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SASH1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SASH1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UCS, and OV are the cancer types where SASH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.749	0.531	<.001	145	view →
UCS	DFS	Median	IV	0.952	0.367	.001	72	view →
OV	OS	Median	III,IV	0.260	0.377	<.001	62	view →
UCEC	DFS	Quartile	All	0.470	0.764	<.001	28	view →
HNSC	DFS	Tertile	All	0.797	0.663	.004	21	view →
LUAD	OS	Tertile	III,IV	0.514	0.277	.007	17	view →
COAD	DFS	Tertile	II,III,IV	0.316	0.692	.009	13	view →
UVM	OS	Quartile	II,III,IV	0.942	0.586	.017	9	view →
KICH	OS	Quartile	III,IV	0.433	1.000	.013	8	view →
STAD	OS	Tertile	All	0.607	0.803	.027	6	view →
BRCA	DFS	Quartile	IV	0.807	0.247	.004	6	view →
GBM	OS	Median	All	0.508	0.299	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SASH1–KIRC (OS)

Open the KIRC breakdown →