SASH1

Across TCGA pan-cancer cohorts, SASH1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SASH1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SASH1 RNA is repressed in tumor relative to normal tissue. In most cancer types SASH1 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where SASH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SASH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−1.853	<.001	11	view →
THCA	Male	III,IV	−1.561	<.001	10	view →
LUAD	Female	III,IV	−2.077	<.001	9	view →
KICH	Female	All	−1.885	<.001	8	view →
LUSC	Female	II,III,IV	−2.045	<.001	7	view →
COAD	All	All	−0.535	<.001	7	view →
BRCA	All	III,IV	−1.272	<.001	6	view →
UCEC	All	All	−1.063	<.001	6	view →
BLCA	All	All	−0.596	.006	4	view →
READ	Female	All	−1.274	.020	2	view →
CHOL	All	All	+0.926	.003	2	view →
PRAD	All	All	+0.622	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SASH1–HNSC

Open the HNSC breakdown →