SASH1

Across TCGA patient cohorts, SASH1 mutation is significantly associated with the RNA expression of many other genes, with 3,878 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SASH1-associated genes across cancer lineages are RCC1, GINS3, and RPL23AP82. Each is linked with SASH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SASH1-to-partner and partner-to-SASH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by SASH1-low versus SASH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH1→partner) and Y-score (partner→SASH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCC1 →	+0.516	+3.960	<.001	<.001	3	4
UCEC	GINS3 →	+0.374	+2.102	<.001	<.001	3	4
UCEC	RPL23AP82 →	+0.325	+2.896	<.001	<.001	3	4
UCEC	NUSAP1 →	+0.617	+1.966	<.001	<.001	3	4
UCEC	UHRF1 →	+0.815	+1.977	<.001	<.001	3	3
LIHC	PGAM4P1 →	+0.106	+4.429	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,878 associations by consensus.

RCC1 by SASH1 expression — COAD

Explore this box plot interactively →