SASH1

Across TCGA pan-cancer cohorts, SASH1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SASH1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SASH1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SASH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, GBM, and PDAC are the cancer types where SASH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.932	0.759	.001	70	view →
GBM	DFS	Quartile	All	0.652	0.275	<.001	13	view →
PDAC	OS	Tertile	III,IV	0.969	0.573	.006	9	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.331	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SASH1–HNSC (OS)

Open the HNSC breakdown →