SASH1

Across TCGA pan-cancer cohorts, SASH1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SASH1 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher SASH1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated SASH1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

STAD, LIHC, and UCEC are the cancer types where SASH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	1.000	0.395	.014	20	view →
LIHC	DFS	Median	All	0.122	0.557	.002	12	view →
UCEC	DFS	Median	All	0.886	0.603	.013	10	view →
CHOL	OS	Median	All	0.089	0.727	.001	9	view →
LUSC	DFS	Median	II,III,IV	0.315	0.619	.002	9	view →
BLCA	DFS	Median	III,IV	0.835	0.257	.010	6	view →
PRAD	DFS	Median	All	0.444	0.888	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SASH1–STAD (OS)

Open the STAD breakdown →