SASH1

Across TCGA cell cohorts, SASH1 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SASH1-associated genes across cancer lineages are CALHM4, OR6V1, and CST2. Each is linked with SASH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASH1-to-partner and partner-to-SASH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CALHM4 grouped by SASH1-low versus SASH1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH1→partner) and Y-score (partner→SASH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CALHM4 →	+0.214	+4.087	<.001	<.001	3	2
BLOOD_Lymphoma	OR6V1 →	+0.014	+3.169	<.001	.008	3	2
BLOOD_Leukemia	CST2 →	+0.489	+2.982	<.001	.007	3	2
BLOOD_Leukemia	C1QTNF9 →	+0.024	+3.174	.002	.004	3	2
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP2-4 →	+0.049	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

CALHM4 by SASH1 expression — BLOOD_Lymphoma

Explore this box plot interactively →