SASH1

Across TCGA patient cohorts, SASH1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SASH1-associated genes across cancer lineages are 4E-BP1, ATM, and Caspase-7-cleavedD198. Each is linked with SASH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SASH1-to-partner and partner-to-SASH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SASH1-low versus SASH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH1→partner) and Y-score (partner→SASH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.331	+2.459	.023	.020	3	4
COAD	ATM →	-0.480	-3.000	.006	.034	3	3
COAD	Caspase-7-cleavedD198 →	+1.577	+3.016	<.001	.018	3	3
UCEC	p90 RSK →	+0.122	+1.584	.020	.032	3	3
UCEC	PCNA →	+0.201	+2.129	<.001	<.001	3	3
UCEC	cIAP →	+0.087	+1.233	.020	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

4E-BP1 by SASH1 expression — SKCM

Explore this box plot interactively →