mannosidase alpha class 1A member 1Genealiases: HUMM3 · HUMM9 · MAN9
Q-omics provides the consensus-scored MAN1A1 profile across patient tissues and cancer cell-line models. MAN1A1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, MAN1A1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, MAN1A1 protein abundance shows 23,206 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight SKCM, KIRC, and LSCC as cancer lineages where MAN1A1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAN1A1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAN1A1 survival associations across molecular data types. MAN1A1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (3) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAN1A1 RNA expression–survival associations across cancer types. High MAN1A1 expression shows unfavorable associations in UVM and GBM, but favorable associations in SKCM, KIRC, LUAD and UCEC. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for MAN1A1 RNA expression.
This table summarizes MAN1A1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for MAN1A1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAN1A1 shows lower tumor expression in KIRC, COAD, KIRP, LUAD, THCA and UCEC. The KIRC box plot shows higher MAN1A1 RNA expression in normal versus tumor tissue (log2 FC = −1.570, t-test p < 0.001).
This table shows molecular features associated with MAN1A1 in patient tissues and cancer cell lines. In patient samples, MAN1A1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, MAN1A1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BONE.
