MAN1A1

Across TCGA pan-cancer cohorts, MAN1A1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MAN1A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAN1A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MAN1A1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and LSCC are the cancer types where MAN1A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAN1A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.361	<.001	10	view →
LUAD	Female	II,III,IV	−0.365	<.001	8	view →
LSCC	Male	II,III,IV	−0.515	<.001	7	view →
HNSC	Male	III,IV	−0.242	<.001	7	view →
CCRCC	Male	III,IV	−0.346	<.001	6	view →
PDAC	All	All	−0.251	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MAN1A1–COAD

Open the COAD breakdown →