MAN1A1

Across TCGA pan-cancer cohorts, MAN1A1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated MAN1A1 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MAN1A1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MAN1A1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and LUAD are the cancer types where MAN1A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.428	0.250	<.001	87	view →
KIRC	DFS	Quartile	All	0.874	0.677	.003	76	view →
LUAD	OS	Median	All	0.741	0.627	.002	56	view →
UVM	OS	Quartile	II,III,IV	0.710	0.975	.006	54	view →
UCEC	OS	Tertile	II,III,IV	0.914	0.757	.002	36	view →
GBM	DFS	Tertile	All	0.171	0.347	<.001	30	view →
LIHC	OS	Tertile	All	0.688	0.905	.002	27	view →
CESC	DFS	Median	All	0.421	0.669	.013	24	view →
PAAD	DFS	Tertile	All	0.406	0.261	.018	23	view →
STAD	OS	Median	III,IV	0.369	0.605	.023	20	view →
SCLC	DFS	Quartile	All	0.422	0.134	.010	20	view →
OV	DFS	Quartile	II,III,IV	0.490	0.588	.021	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

MAN1A1–SKCM (OS)

Open the SKCM breakdown →