MAN1A1

Across TCGA pan-cancer cohorts, MAN1A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MAN1A1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MAN1A1 RNA is repressed in tumor relative to normal tissue. In most cancer types MAN1A1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where MAN1A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAN1A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.570	<.001	12	view →
COAD	Female	All	−1.747	<.001	11	view →
KIRP	Female	All	−1.692	<.001	11	view →
LUAD	All	II,III,IV	−0.702	<.001	10	view →
THCA	Female	II,III,IV	−1.583	<.001	9	view →
UCEC	All	All	−1.517	<.001	6	view →
LUSC	Female	All	−1.548	<.001	5	view →
KICH	All	All	−0.914	<.001	4	view →
LIHC	Female	All	−0.872	<.001	4	view →
HNSC	Female	All	+0.846	.002	4	view →
BRCA	Female	All	−0.506	<.001	4	view →
CHOL	All	All	−1.781	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MAN1A1–KIRC

Open the KIRC breakdown →