MAN1A1

Across TCGA cell cohorts, MAN1A1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAN1A1-associated genes across cancer lineages are IGSF21, DEFB124, and FAM24A. Each is linked with MAN1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN1A1-to-partner and partner-to-MAN1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF21 grouped by MAN1A1-low versus MAN1A1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1A1→partner) and Y-score (partner→MAN1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IGSF21 →	+0.133	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	DEFB124 →	+0.130	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	FAM24A →	+0.044	+4.662	<.001	.003	3	1
BLOOD_Lymphoma	LDLRAD1 →	+0.027	+4.459	.002	.001	3	1
OVARY	CST9 →	+0.006	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	IL2 →	+0.029	+5.149	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IGSF21 by MAN1A1 expression — BLOOD_Lymphoma

Explore this box plot interactively →