MAN1A1

Across TCGA pan-cancer cohorts, MAN1A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MAN1A1 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MAN1A1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MAN1A1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where MAN1A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.256	0.687	.014	19	view →
LSCC	OS	Median	All	0.920	1.000	.008	11	view →
CCRCC	OS	Tertile	All	1.000	0.867	.019	10	view →
PDAC	DFS	Quartile	All	0.191	0.419	.007	5	view →
UCEC	DFS	Quartile	All	0.833	1.000	.008	4	view →
GBM	OS	Tertile	All	0.783	0.980	.010	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MAN1A1–LUAD (OS)

Open the LUAD breakdown →