MAN1A1

Across TCGA patient cohorts, MAN1A1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN1A1-associated genes across cancer lineages are Notch1, p62 Lck ligand, and PDCD4. Each is linked with MAN1A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN1A1-to-partner and partner-to-MAN1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MAN1A1-low versus MAN1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1A1→partner) and Y-score (partner→MAN1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.158	+2.594	.002	.006	3	3
UCEC	p62 Lck ligand →	+0.315	+2.169	.009	.003	3	3
UCEC	PDCD4 →	-0.559	-2.105	.001	.017	3	2
UCEC	Annexin-1 →	+0.756	+3.720	<.001	<.001	3	2
SKCM	Cyclin-B1 →	+0.382	+2.472	.031	.010	3	2
UCEC	MEK1 →	+0.403	+2.662	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by MAN1A1 expression — UCEC

Explore this box plot interactively →