MAN1A1

Across TCGA cell cohorts, MAN1A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,571 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAN1A1-associated GO terms across cancer lineages are Golgi apparatus N-glycan mannose trimming, Response to glycoprotein, and Endocytic recycling. Each is linked with MAN1A1 in more than 14 cancer types. Because this analysis shows association rather than direction, both MAN1A1-to-partner and partner-to-MAN1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi apparatus N-glycan mannose trimming grouped by MAN1A1-low versus MAN1A1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1A1→partner) and Y-score (partner→MAN1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Golgi apparatus N-glycan mannose trimming →	+0.980	+3.477	<.001	<.001	3	15
LUNG_SCLC	Response to glycoprotein →	+0.925	+2.593	<.001	<.001	3	10
BONE	Endocytic recycling →	+0.063	+2.367	<.001	<.001	3	10
CNS	Protein localization to lysosome →	+0.045	+1.107	<.001	<.001	3	9
LUNG_SCLC	Mannose trimming involved in glycoprotein ERAD pathway →	+0.462	+2.425	.007	<.001	2	10
LUNG_SCLC	Protein deglycosylation involved in glycoprotein catabolic process →	+0.462	+2.425	.007	<.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,571 associations by consensus.

Golgi apparatus N-glycan mannose trimming by MAN1A1 expression — BONE

Explore this box plot interactively →