MAN1A1

Across TCGA patient cohorts, MAN1A1 mutation is significantly associated with the RNA expression of many other genes, with 2,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN1A1-associated genes across cancer lineages are WDR5, SNORD114-18, and INCENP. Each is linked with MAN1A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN1A1-to-partner and partner-to-MAN1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR5 grouped by MAN1A1-low versus MAN1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN1A1→partner) and Y-score (partner→MAN1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR5 →	+0.496	+2.424	<.001	<.001	3	3
UCEC	SNORD114-18 →	+0.270	+2.299	.003	.004	3	3
UCEC	INCENP →	+0.612	+2.423	.002	.001	3	3
UCEC	DHX37 →	+0.472	+2.914	<.001	.001	3	3
UCEC	EME1 →	+0.543	+2.403	.001	<.001	3	3
UCEC	SLC4A2 →	+0.589	+2.032	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,494 associations by consensus.

WDR5 by MAN1A1 expression — UCEC

Explore this box plot interactively →