Q-omics provides the consensus-scored HAUS4 profile across patient tissues and cancer cell-line models. HAUS4 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, HAUS4 is differentially expressed in 12, with the highest sampling consensus in LIHC. Additionally, HAUS4 RNA expression shows 18,565 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight BLCA, LIHC, and ACC as cancer lineages where HAUS4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HAUS4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HAUS4 survival associations across molecular data types. HAUS4 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (5) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HAUS4 RNA expression–survival associations across cancer types. High HAUS4 expression shows unfavorable associations in BLCA, ACC, KIRP and KICH, but favorable associations in KIRC and LGG. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for HAUS4 RNA expression.
This table summarizes HAUS4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 4. The strongest signals are observed in LIHC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HAUS4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HAUS4 shows lower tumor expression in UCEC, BRCA and KICH and higher tumor expression in LIHC, KIRC and HNSC. The LIHC box plot shows higher HAUS4 RNA expression in tumor versus normal tissue (log2 FC = +1.080, t-test p < 0.001).
This table shows molecular features associated with HAUS4 in patient tissues and cancer cell lines. In patient samples, HAUS4 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, HAUS4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and SOFT_TISSUE.
