HAUS4

Across TCGA patient cohorts, HAUS4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAUS4-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and ERK2. Each is linked with HAUS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAUS4-to-partner and partner-to-HAUS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HAUS4-low versus HAUS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAUS4→partner) and Y-score (partner→HAUS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.904	+2.189	.001	.034	3	2
UCEC	14-3-3_beta →	-0.137	-2.571	.003	.011	3	1
UCEC	ERK2 →	+0.256	+3.321	.004	.010	3	1
UCEC	MEK1 →	+0.387	+3.169	.023	.019	3	1
UCEC	MSH2 →	-0.493	-3.295	<.001	.009	3	1
UCEC	MSH6 →	-0.485	-2.999	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Caspase-7-cleavedD198 by HAUS4 expression — UCEC

Explore this box plot interactively →