HAUS4

Across TCGA pan-cancer cohorts, HAUS4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HAUS4’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where HAUS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HAUS4 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

LIHC, UCEC, and KIRC are the cancer types where HAUS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAUS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+1.080	<.001	8	view →
UCEC	All	All	−0.916	<.001	6	view →
KIRC	All	All	+0.339	<.001	6	view →
HNSC	All	III,IV	+0.398	.020	4	view →
BRCA	Female	All	−0.308	<.001	4	view →
KICH	Female	All	−0.968	<.001	3	view →
KIRP	All	II,III,IV	+0.508	.008	3	view →
CHOL	All	All	+1.096	<.001	2	view →
BLCA	Female	III,IV	+0.541	.029	2	view →
LUAD	All	All	+0.324	<.001	2	view →
PRAD	All	All	−0.261	.025	2	view →
LUSC	All	III,IV	−0.585	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HAUS4–LIHC

Open the LIHC breakdown →