HAUS4

Across TCGA pan-cancer cohorts, HAUS4 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HAUS4’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where HAUS4 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HAUS4 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

CCRCC, HNSC, and LSCC are the cancer types where HAUS4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAUS4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.505	<.001	11	view →
HNSC	All	IV	+0.354	<.001	11	view →
LSCC	Male	II,III,IV	+0.173	<.001	6	view →
LUAD	Female	All	−0.116	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HAUS4–CCRCC

Open the CCRCC breakdown →