transmembrane protein 254Genealiases: C10orf57 · bA369J21.6
Q-omics provides the consensus-scored TMEM254 profile across patient tissues and cancer cell-line models. TMEM254 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in OV. Among the 18 cancer types available for tumor–normal comparison, TMEM254 is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, TMEM254 RNA expression shows 19,745 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight OV, KICH, and ACC as cancer lineages where TMEM254 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM254 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM254 survival associations across molecular data types. TMEM254 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (2) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM254 RNA expression–survival associations across cancer types. High TMEM254 expression shows unfavorable associations in ACC and KICH, but favorable associations in OV, LGG, UVM and KIRC. The OV Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify OV as the clearest survival context for TMEM254 RNA expression.
This table summarizes TMEM254 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 7. The strongest signals are observed in KICH for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TMEM254. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM254 shows lower tumor expression in KICH, THCA and COAD and higher tumor expression in LUAD, LUSC and BRCA. The KICH box plot shows higher TMEM254 RNA expression in normal versus tumor tissue (log2 FC = −1.279, t-test p < 0.001).
This table shows molecular features associated with TMEM254 in patient tissues and cancer cell lines. In patient samples, TMEM254 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TMEM254 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
