TMEM254

Across TCGA pan-cancer cohorts, TMEM254 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TMEM254 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TMEM254 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TMEM254 expression acts as an unfavorable survival marker, although some lineages such as OV and LGG show a favorable association.

OV, ACC, and LGG are the cancer types where TMEM254 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	All	0.607	0.477	.002	90	view →
ACC	DFS	Tertile	All	0.192	0.729	<.001	48	view →
LGG	DFS	Median	All	0.476	0.311	<.001	45	view →
UVM	OS	Tertile	All	1.000	0.639	.002	35	view →
KIRC	DFS	Tertile	All	0.879	0.727	.011	22	view →
KICH	DFS	Median	II,III,IV	0.705	0.960	.010	20	view →
READ	DFS	Median	All	0.840	0.367	.011	16	view →
HNSC	OS	Median	IV	0.561	0.721	.007	15	view →
PRAD	DFS	Median	All	0.926	0.844	.002	14	view →
BLCA	DFS	Tertile	All	0.563	0.680	.018	10	view →
ESCA	OS	Tertile	All	1.000	0.546	.018	9	view →
CHOL	DFS	Tertile	III,IV	0.232	0.779	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TMEM254–OV (DFS)

Open the OV breakdown →