TMEM254

Across TCGA patient cohorts, TMEM254 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM254-associated genes across cancer lineages are PI3K-p85 and ERK2. Each is linked with TMEM254 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM254-to-partner and partner-to-TMEM254 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by TMEM254-low versus TMEM254-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM254→partner) and Y-score (partner→TMEM254) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.249	+3.169	.030	.020	3	1
UCEC	ERK2 →	+0.276	+3.169	.009	.020	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PI3K-p85 by TMEM254 expression — UCEC

Explore this box plot interactively →