Q-omics provides the consensus-scored SPINK5 profile across patient tissues and cancer cell-line models. SPINK5 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SPINK5 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, SPINK5 RNA expression shows 14,547 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, HNSC, and THYM as cancer lineages where SPINK5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPINK5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPINK5 survival associations across molecular data types. SPINK5 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (11) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPINK5 RNA expression–survival associations across cancer types. High SPINK5 expression shows unfavorable associations in UVM, but favorable associations in KIRC, HNSC, LGG, MESO and LUSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SPINK5 RNA expression.
This table summarizes SPINK5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SPINK5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPINK5 shows lower tumor expression in HNSC, COAD, THCA and BRCA and higher tumor expression in KIRC and LIHC. The HNSC box plot shows higher SPINK5 RNA expression in normal versus tumor tissue (log2 FC = −4.125, t-test p < 0.001).
This table shows molecular features associated with SPINK5 in patient tissues and cancer cell lines. In patient samples, SPINK5 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SPINK5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
