SPINK5

Across TCGA cell cohorts, SPINK5 mutation is significantly associated with the RNA expression of many other genes, with 449 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPINK5-associated genes across cancer lineages are ASB18, KRTAP20-2, and MAGEB4. Each is linked with SPINK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK5-to-partner and partner-to-SPINK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB18 grouped by SPINK5-low versus SPINK5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK5→partner) and Y-score (partner→SPINK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB18 →	+0.035	+5.539	<.001	.003	3	2
OVARY	KRTAP20-2 →	+0.096	+4.781	<.001	<.001	3	1
SKIN	MAGEB4 →	+0.006	+4.022	<.001	.006	3	1
SKIN	SPAG11A →	+0.036	+4.022	<.001	.006	3	1
SKIN	KRTAP6-1 →	+0.050	+4.022	<.001	.006	3	1
SKIN	RTP2 →	+0.019	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 449 associations by consensus.

ASB18 by SPINK5 expression — BLOOD_Leukemia

Explore this box plot interactively →