SPINK5

Across TCGA pan-cancer cohorts, SPINK5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPINK5 data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPINK5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPINK5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, UVM, and HNSC are the cancer types where SPINK5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.674	0.351	<.001	95	view →
UVM	DFS	Median	III,IV	0.382	0.927	<.001	65	view →
HNSC	DFS	Quartile	All	0.754	0.621	.002	57	view →
LGG	DFS	Median	All	0.521	0.267	<.001	54	view →
MESO	OS	Median	All	0.669	0.436	.002	49	view →
LUSC	DFS	Quartile	II,III,IV	0.672	0.391	.001	47	view →
SKCM	OS	Quartile	All	0.817	0.914	.001	29	view →
UCEC	DFS	Median	III,IV	0.857	0.729	.010	22	view →
ACC	DFS	Median	II,III,IV	0.241	0.603	.009	19	view →
CESC	DFS	Median	All	0.874	0.766	.003	16	view →
SARC	DFS	Quartile	All	0.685	0.499	.010	15	view →
BLCA	DFS	Quartile	II,III,IV	0.242	0.412	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPINK5–KIRC (DFS)

Open the KIRC breakdown →