SPINK5

Across TCGA pan-cancer cohorts, SPINK5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPINK5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPINK5 RNA is repressed in tumor relative to normal tissue. In most cancer types SPINK5 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where SPINK5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPINK5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−4.125	<.001	12	view →
KIRC	All	III,IV	+0.745	<.001	11	view →
COAD	All	II,III,IV	−1.194	<.001	10	view →
LIHC	All	II,III,IV	+0.741	<.001	7	view →
THCA	All	All	−0.576	.003	7	view →
BRCA	All	All	−0.795	<.001	6	view →
READ	All	All	−2.673	<.001	5	view →
BLCA	Male	All	+2.303	<.001	3	view →
LUSC	Male	All	+1.134	.001	2	view →
UCEC	All	All	+0.992	.033	2	view →
PRAD	All	All	−0.555	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPINK5–HNSC

Open the HNSC breakdown →