SPINK5

Across TCGA patient cohorts, SPINK5 mutation is significantly associated with the RNA expression of many other genes, with 3,346 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK5-associated genes across cancer lineages are DSCR10, HIRIP3, and BAG3. Each is linked with SPINK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINK5-to-partner and partner-to-SPINK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR10 grouped by SPINK5-low versus SPINK5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK5→partner) and Y-score (partner→SPINK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSCR10 →	+0.404	+4.553	<.001	.005	3	3
UCEC	HIRIP3 →	+0.348	+1.776	.001	<.001	3	3
UCEC	BAG3 →	+0.384	+1.253	.004	.006	3	3
UCEC	GPHN →	+0.375	+3.119	.001	<.001	3	3
UCEC	ENO1 →	+0.362	+2.539	.006	<.001	3	3
SKCM	EMID1 →	-0.609	-1.362	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,346 associations by consensus.

DSCR10 by SPINK5 expression — BRCA

Explore this box plot interactively →