SPINK5

Across TCGA patient cohorts, SPINK5 protein abundance is significantly associated with the RNA expression of many other genes, with 7,732 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPINK5-associated genes across cancer lineages are SLC39A2, PTK6, and CNFN. Each is linked with SPINK5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPINK5-to-partner and partner-to-SPINK5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK5 versus SLC39A2 in HNSC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK5→partner) and Y-score (partner→SPINK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SLC39A2 →	+1.084	+0.555	<.001	<.001	3	3
HNSC	PTK6 →	+1.099	+0.924	<.001	<.001	3	3
HNSC	CNFN →	+2.193	+0.829	<.001	<.001	3	3
UCEC	TTK →	-0.792	-1.623	.007	.001	3	3
UCEC	LYPD3 →	+2.022	+2.228	.001	.001	3	3
UCEC	S100A7 →	+4.644	+1.953	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,732 associations by consensus.

SPINK5 vs SLC39A2 — HNSC

Explore this scatter interactively →