SPINK5

Across TCGA pan-cancer cohorts, SPINK5 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SPINK5 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher SPINK5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPINK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, BRCA, and DLBC are the cancer types where SPINK5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.361	0.842	.004	18	view →
BRCA	OS	Median	III,IV	0.027	0.907	<.001	16	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
PAAD	OS	Median	All	0.112	0.640	.004	12	view →
LIHC	OS	Median	II,III,IV	0.033	0.716	<.001	12	view →
READ	DFS	Median	II,III,IV	0.269	0.799	.018	9	view →
UCEC	DFS	Median	All	0.797	0.629	.024	8	view →
COAD	OS	Median	III,IV	0.054	0.793	<.001	6	view →
STAD	OS	Median	III,IV	0.169	0.641	.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	III,IV	0.124	0.662	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SPINK5–OV (OS)

Open the OV breakdown →