SPINK5

Across TCGA pan-cancer cohorts, SPINK5 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPINK5 data layer compared with 22 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPINK5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPINK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where SPINK5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.732	.001	16	view →
HNSC	OS	Median	All	1.000	0.484	.038	13	view →
LSCC	DFS	Quartile	II,III,IV	0.248	0.831	.038	5	view →
CCRCC	OS	Median	II,III,IV	0.615	0.915	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPINK5–UCEC (DFS)

Open the UCEC breakdown →