N-deacetylase and N-sulfotransferase 1Genealiases: HSST · MRT46 · NST1
Q-omics provides the consensus-scored NDST1 profile across patient tissues and cancer cell-line models. NDST1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, NDST1 is differentially expressed in 11, with the highest sampling consensus in LIHC. Additionally, NDST1 RNA expression shows 19,851 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight MESO, LIHC, and THYM as cancer lineages where NDST1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NDST1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NDST1 survival associations across molecular data types. NDST1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (8) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NDST1 RNA expression–survival associations across cancer types. High NDST1 expression shows unfavorable associations in MESO, OV, SKCM, KICH and LUSC, but favorable associations in KIRC. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for NDST1 RNA expression.
This table summarizes NDST1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 8. The strongest signals are observed in LIHC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for NDST1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NDST1 shows lower tumor expression in LUAD, LUSC, BRCA and COAD and higher tumor expression in LIHC and KIRC. The LIHC box plot shows higher NDST1 RNA expression in tumor versus normal tissue (log2 FC = +2.050, t-test p < 0.001).
This table shows molecular features associated with NDST1 in patient tissues and cancer cell lines. In patient samples, NDST1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, NDST1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
